nips nips2011 nips2011-173 nips2011-173-reference knowledge-graph by maker-knowledge-mining

173 nips-2011-Modelling Genetic Variations using Fragmentation-Coagulation Processes


Source: pdf

Author: Yee W. Teh, Charles Blundell, Lloyd Elliott

Abstract: We propose a novel class of Bayesian nonparametric models for sequential data called fragmentation-coagulation processes (FCPs). FCPs model a set of sequences using a partition-valued Markov process which evolves by splitting and merging clusters. An FCP is exchangeable, projective, stationary and reversible, and its equilibrium distributions are given by the Chinese restaurant process. As opposed to hidden Markov models, FCPs allow for flexible modelling of the number of clusters, and they avoid label switching non-identifiability problems. We develop an efficient Gibbs sampler for FCPs which uses uniformization and the forward-backward algorithm. Our development of FCPs is motivated by applications in population genetics, and we demonstrate the utility of FCPs on problems of genotype imputation with phased and unphased SNP data. 1


reference text