nips nips2005 nips2005-67 nips2005-67-reference knowledge-graph by maker-knowledge-mining
Source: pdf
Author: Afsheen Afshar, Gopal Santhanam, Stephen I. Ryu, Maneesh Sahani, Byron M. Yu, Krishna V. Shenoy
Abstract: Spiking activity from neurophysiological experiments often exhibits dynamics beyond that driven by external stimulation, presumably reflecting the extensive recurrence of neural circuitry. Characterizing these dynamics may reveal important features of neural computation, particularly during internally-driven cognitive operations. For example, the activity of premotor cortex (PMd) neurons during an instructed delay period separating movement-target specification and a movementinitiation cue is believed to be involved in motor planning. We show that the dynamics underlying this activity can be captured by a lowdimensional non-linear dynamical systems model, with underlying recurrent structure and stochastic point-process output. We present and validate latent variable methods that simultaneously estimate the system parameters and the trial-by-trial dynamical trajectories. These methods are applied to characterize the dynamics in PMd data recorded from a chronically-implanted 96-electrode array while monkeys perform delayed-reach tasks. 1
[1] M. Abeles, H. Bergman, I. Gat, I. Meilijson, E. Seidemann, N. Tishby, and E. Vaadia. Proc Natl Acad Sci USA, 92:8616–8620, 1995.
[2] I. Gat, N. Tishby, and M. Abeles. Network, 8(3):297–322, 1997.
[3] A. Smith and E. Brown. Neural Comput, 15(5):965–991, 2003.
[4] S. Amari. Biol Cybern, 27(2):77–87, 1977.
[5] A. Dempster, N. Laird, and D. Rubin. J R Stat Soc Ser B, 39:1–38, 1977.
[6] S. Julier and J. Uhlmann. In Proc. AeroSense: 11th Int. Symp. Aerospace/Defense Sensing, Simulation and Controls, pp. 182–193, 1997.
[7] U. Lerner. Hybrid Bayesian networks for reasoning about complex systems. PhD thesis, Stanford University, Stanford, CA, 2002.
[8] J. Tanji and E. Evarts. J Neurophysiol, 39:1062–1068, 1976.
[9] M. Weinrich, S. Wise, and K. Mauritz. Brain, 107:385–414, 1984.
[10] M. Godschalk, R. Lemon, H. Kuypers, and J. van der Steen. Behav Brain Res, 18:143–157, 1985.
[11] A. Riehle and J. Requin. J Neurophysiol, 61:534–549, 1989.
[12] D. Crammond and J. Kalaska. J Neurophysiol, 84:986–1005, 2000.
[13] J. Messier and J. Kalaska. J Neurophysiol, 84:152–165, 2000.
[14] D. Rosenbaum. J Exp Psychol Gen, 109:444–474, 1980.
[15] A. Riehle and J. Requin. J Behav Brain Res, 53:35–49, 1993.
[16] M. Churchland, B. Yu, S. Ryu, G. Santhanam, and K. Shenoy. Soc. for Neurosci. Abstr., 2004.
[17] E. Brown, R. Barbieri, V. Ventura, R. Kass, and L. Frank. Neural Comput, 14(2):325– 346, 2002.