nips nips2002 nips2002-180 nips2002-180-reference knowledge-graph by maker-knowledge-mining

180 nips-2002-Selectivity and Metaplasticity in a Unified Calcium-Dependent Model


Source: pdf

Author: Luk Chong Yeung, Brian S. Blais, Leon N. Cooper, Harel Z. Shouval

Abstract: A unified, biophysically motivated Calcium-Dependent Learning model has been shown to account for various rate-based and spike time-dependent paradigms for inducing synaptic plasticity. Here, we investigate the properties of this model for a multi-synapse neuron that receives inputs with different spike-train statistics. In addition, we present a physiological form of metaplasticity, an activity-driven regulation mechanism, that is essential for the robustness of the model. A neuron thus implemented develops stable and selective receptive fields, given various input statistics 1


reference text

[1] T.V.P. Bliss and G.L. Collingridge. A synaptic model of memory; long-term potentiation the hippocampus. Nature, 361:31–9, 1993.

[2] S.M. Dudek and M.F. Bear. Homosynaptic long-term depression in area CA1 of hippocampus and the effects on NMDA receptor blockade. Proc. Natl. Acad. Sci., 89:4363–7, 1992.

[3] H. Markram, J. L¨bke, M. Frotscher, and B. Sakmann. Regulation of synaptic efficacy u by coincidence of postsynaptic APs and EPSPs. Science, 275:213–5, 1997.

[4] G. Bi and M. Poo. Synaptic modifications in cultured hippocampal neurons: Dependence on spike timing, synaptic strength, and postsynaptic cell type. J. Neurosci., 18 (24):10464–72, 1998.

[5] A. Kleinschmidt, M.F. Bear, and W. Singer. Blockade of NMDA receptors disrupts experience-dependent plasticity of kitten striate cortex. Science, 238:355–358, 1987.

[6] M.F. Bear, L.N Cooper, and F.F. Ebner. A physiological basis for a theory of synapse modification. Science, 237:42–8, 1987.

[7] J.A. Lisman. A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory. Proc. Natl. Acad. Sci., 86:9574–8, 1989.

[8] H.Z. Shouval, M.F. Bear, and L.N Cooper. A unified theory of nmda receptordependent bidirectional synaptic plasticity. Proc. Natl. Acad. Sci., 99:10831–6, 2002.

[9] M. Nishiyama, K. Hong, K. Mikoshiba, M.M. Poo, and K. Kato. Calcium stores regulate the polarity and input specificity of synaptic modification. Nature, 408:584– 8, 2000.

[10] P.J. Sj¨str¨m, G.G. Turrigiano, and S.B. Nelson. Rate, timing, and cooperativity o o jointly determine cortical synaptic plasticity. Neuron, 32:1149–64, 2001.

[11] E.L. Bienenstock, L.N Cooper, and P.W. Munro. Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex. J. Neurosci., 2:32–48, 1982.

[12] A. Kirkwood, M.G. Rioult, and M.F. Bear. Experience-dependent modification of synaptic plasticity in visual cortex. Nature, 381:526–8, 1996.

[13] B.D. Philpot, A.K. Sekhar, H.Z. Shouval, and M.F. Bear. Visual experience and deprivation bidirectionally modify the composition and function of NMDA receptors in visual cortex. Neuron, 29:157–69, 2001.

[14] S. Song, K.D. Miller, and L.F. Abbott. Competitive hebbian learning through spiketiming dependent synaptic plasticity. Nature Neurosci., 3:919–26, 2000.

[15] G. Carmignoto and S. Vicini. Activity dependent increase in NMDA receptor responses during development of visual cotex. Science, 258:1007–11, 1992.

[16] E.M. Quinlan, B.D. Philpot, R.L. Huganir, and M.F. Bear. Rapid, experiencedependent expression of synaptic NMDA receptors in visual cortex in vivo. Nature Neurosci., 2(4):352–7, 1999.

[17] A.J. Watt, M.C.W. van Rossum, K.M. MacLeod, S.B. Nelson, and G.G. Turrigiano. Activity co-regulates quantal ampa and nmda currents at neocortical synapses. Neuron, 26:659–70, 2000.

[18] H.Z. Shouval, G.C. Castellani, L.C. Yeung, B.S. Blais, and L.N Cooper. Converging evidence for a simplified biophysical model of synaptic plasticity. Bio. Cyb., 87:383–91, 2002.

[19] Y. Fr´gnac and M. Imbert. Early development of visual cortical cells in normal and e dark reared kittens: relationship between orientation selectivity and ocular dominance. J. Physiol. Lond., 278:27–44, 1978.

[20] B. Chapman, M.P. Stryker, and T. Bonhoeffer. Development of orientation preference maps in ferret primary visual cortex. J. Neurosci., 16:6443–53, 1996.

[21] A.S. Ramoa, A.F. Mower, D. Liao, and S.I. Jafri. Suppression of cortical nmda receptor function prevents development of orientation selectivity in the primary visual cortex. J. Neurosci., 21:4299–309, 2001.

[22] B.S. Blais, H.Z. Shouval, and L.N Cooper. The role of presynaptic activity in monocular deprivation: Comparison of homosynaptic and heterosynaptic mechanisms. Proc. Natl. Acad. Sci., 96:1083–7, 1999.

[23] E.E. Clothiaux, L.N Cooper, and M.F. Bear. Synaptic plasticity in visual cortex: Comparison of theory with experiment. J. Neurophys., 66:1785–804, 1991.

[24] B.L. Sabatini, T.G. Oerthner, and K. Svoboda. The life cycle of ca2+ ions in dendritic spines. Neuron, 33:439–52, 2002.

[25] J.C. Magee and D. Johnston. A synaptically controlled, associative signal for hebbian plasticity in hippocampal neurons. Science, 275:209–13, 1997.

[26] M. Rudolph and A. Destexhe. Correlation detection and resonance in neural systems with distributed noise sources. Phys. Rev. Lett., 86(16):3662–5, 2001.